IONOTROPIC GLUTAMATE RECEPTORS: STILL A TARGET FOR NEUROPROTECTION IN BRAIN ISCHEMIA? INSIGHTS FROM IN VITRO STUDIES

Although experimental studies have widely shown that the pharmacological blockade of ionotropic glutamate receptors reduces ischemic damage, clinical trials with classical AMPA and NMDA glutamate receptor antagonists have provided negative results.To address the involvement of ionotropic glutamate receptors in ischemic damage, corticostriatal brain

Abstract Pooled CRISPR screens are vital in the unbiased interrogation of gene function and are instrumental in uncovering therapeutic targets and biological processes.However, follow-up hit validation is critical to confirm observed results.Researchers need Garbage Chutes a simple and robust approach to rapidly verify putative hits and test result